Local P T symmetry violates the no-signaling principle

Bender et al. [Phys. Rev. Lett. 80, 5243 (1998)] have developed PT-symmetric quantum theory as an extension of quantum theory to non-Hermitian Hamiltonians. We show that when this model has a local PT symmetry acting on composite systems, it violates the nonsignaling principle of relativity. Since the case of global PT symmetry is known to reduce to standard quantum mechanics A. Mostafazadeh [J. Math. Phys. 43, 205 (2001)], this shows that the PT-symmetric theory is either a trivial extension or likely false as a fundamental theory. © 2014 American Physical Society

Electric fields as a means of controlling thin film flow over topography

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.Gravity-driven, steady-state flow of a thin liquid film over a substrate containing topography in the presence of a normal electric field is investigated. The liquid is assumed to be a perfect conductor and the air above it an ideal dielectric. The Navier-Stokes equations are solved using a new depth-averaged approximation that is capable of analysing film flows with inertia, with the flow coupled to the electric field via a Maxwell normal stress term that results from the solution of Laplace’s equation for the electric potential above the film. The latter is solved analytically using separation of variables and Fourier series. The coupled solver is used to analyse the interplay between inertia and electric field effects for flow over onedimensional step and trench topographies and to predict the effect of an electric field on three-dimensional Stokes flow over a two-dimensional trench topography. Sample results are given which investigate the magnitude of the electric fields needed to suppress free surface disturbances induced by topography in each of the cases considered.This study is funded by the European Union via Marie Curie Action Contract MEST-CT-2005-020599

Real-time estimation of lane-based queue lengths at isolated signalized junctions

In this study, we develop a real-time estimation approach for lane-based queue lengths. Our aim is to determine the numbers of queued vehicles in each lane, based on detector information at isolated signalized junctions. The challenges involved in this task are to identify whether there is a residual queue at the start time of each cycle and to determine the proportions of lane-to-lane traffic volumes in each lane. Discriminant models are developed based on time occupancy rates and impulse memories, as calculated by the detector and signal information from a set of upstream and downstream detectors. To determine the proportions of total traffic volume in each lane, the downstream arrivals for each cycle are estimated by using the Kalman filter, which is based on upstream arrivals and downstream discharges collected during the previous cycle. Both the computer simulations and the case study of real-world traffic show that the proposed method is robust and accurate for the estimation of lane-based queue lengths in real time under a wide range of traffic conditions. Calibrated discriminant models play a significant role in determining whether there are residual queued vehicles in each lane at the start time of each cycle. In addition, downstream arrivals estimated by the Kalman filter enhance the accuracy of the estimates by minimizing any error terms caused by lane-changing behavior.postprin

Blended learning for building student-teachers’ capacity to learn and teach science-related interdisciplinary subjects: The case of Hong Kong

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Passive PT -symmetric couplers without complex optical potentials

© 2015 American Physical Society. In addition to the implementation of parity-time-(PT-) symmetric optical systems by carefully and actively controlling the gain and loss, we show that a 2×2 PT-symmetric Hamiltonian has a unitarily equivalent representation without complex optical potentials in the resulting optical coupler. Through the Naimark dilation in operator algebra, passive PT-symmetric couplers can thus be implemented with a refractive index of real values and asymmetric coupling coefficients. This opens up the possibility to implement general PT-symmetric systems with state-of-the-art asymmetric slab waveguides, dissimilar optical fibers, or cavities with chiral mirrors

Self-report poor oral health and chronic diseases: the Hong Kong FAMILY project

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Effect of Al addition on microstructure of AZ91D

Casting is a net shape or near net shape forming process so work-hardening will not be applicable for improving properties of magnesium cast alloys. Grain refinement, solid-solution strengthening, precipitation hardening and specially designed heat treatment are the techniques used to enhance the properties of these alloys. This research focusses on grain refinement of magnesium alloy AZ91D, which is a widely used commercial cast alloy. Recently, Al-B based master alloys have shown potential in grain refining AZ91D. A comparative study of the grain refinement of AZ91D by addition of 0.02wt%B, 0.04wt%B, 0.1wt%B, 0.5wt%B and 1.0wt%B of A1-5B master alloy and equivalent amount of solute element aluminium is described in this paper. Hardness profile of AZ91D alloyed with boron and aluminium is compared

Signal processing techniques for synchronization of wireless sensor networks

Plenary PaperClock synchronization is a critical component in wireless sensor networks, as it provides a common time frame to different nodes. It supports functions such as fusing voice and video data from different sensor nodes, time-based channel sharing, and sleep wake-up scheduling, etc. Early studies on clock synchronization for wireless sensor networks mainly focus on protocol design. However, clock synchronization problem is inherently related to parameter estimation, and recently, studies of clock synchronization from the signal processing viewpoint started to emerge. In this article, a survey of latest advances on clock synchronization is provided by adopting a signal processing viewpoint. We demonstrate that many existing and intuitive clock synchronization protocols can be interpreted by common statistical signal processing methods. Furthermore, the use of advanced signal processing techniques for deriving optimal clock synchronization algorithms under challenging scenarios will be illustrated. © 2010 SPIE.published_or_final_versio

Modeling pegylated liposomal doxorubicin-induced hand-foot syndrome and intestinal mucositis in zebrafish

[[abstract]]Pegylated liposomal doxorubicin (PLD) has been widely used to treat cancer. The adverse effects of PLD noted in clinical practice, especially hand-foot syndrome (HFS), are regarded as unique, and the management methods for them remain limited. This study was aimed at developing a feasible experimental model for translational medicine to solve this clinical issue by using skin fluorescent transgenic zebrafish. We established an optimal protocol for the administration of Lipo-Dox™, a PLD in current clinical use, to the Tg(k18:dsred) zebrafish line expressing red fluorescence in keratinocytes. We made use of bodyweight, survival rate, gross observation, flssuorescent microscopic assessment, and pathological examination of the zebrafish to assess this model. The consecutive administration protocol of PLD resulted in growth retardation of the zebrafish embryo and survival impairment, indicating establishment of a significant toxicity. We observed fin necrosis and keratinocyte dissociation phenotypes in the PLD-treated fish after consecutive administration. The skin toxicity induced by the Lipo-Dox injection was subsequently reversible, which might be compatible with a clinical course of skin recovery after discontinuation of Lipo-Dox administration. Furthermore, we found that the number of intestinal goblet cells, an important marker of intestinal inflammation, in the Lipo-Dox-injected zebrafish was markedly increased, accompanied by impaired mucosal integrity. The intestinal inflammation induced by Lipo-Dox resembled the intestinal mucositis the clinical patients suffered from after the administration of PLD. In conclusion, we established a zebrafish model for PLD-induced HFS. The intestinal mucositis simultaneously noted in the PLD-treated zebrafish validated the similarity of clinical courses after administration of PLD. This model is easily assessable, efficient, and worthy for use in developing a new therapeutic protocol for prevention or treatment of HFS as well as intestinal mucositis. Further clinical investigations to validate the correlation between human and zebrafish data are warranted.[[journaltype]]國外[[ispeerreviewed]]Y[[booktype]]電子版[[countrycodes]]GB

KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes

Identification of novel biomarkers for tumor-initiating cells (TICs) is of critical importance for developing diagnostic and therapeutic strategies against cancers. Here we identified the role of KIAA1114, a full-length translational product of the trophinin gene, as a distinctive marker for TICs in human liver cancer by developing a DNA vaccine-induced monoclonal antibody targeting the putative extracellular domain of KIAA1114. Compared with other established markers of liver TICs, KIAA1114 was unique in that its expression was detected in both alpha fetoprotein (AFP)-positive and AFP-negative hepatocellular carcinoma (HCC) cell lines with the expression levels of KIAA1114 being positively correlated to their tumorigenic potentials. Notably, KIAA1114 expression was strongly detected in primary hepatic tumor, but neither in the adjacent non-tumorous tissue from the same patient nor normal liver tissue. KIAA1114(high) cells isolated from HCC cell lines displayed TIC-like features with superior functional and phenotypic traits compared to their KIAA1114(low) counterparts, including tumorigenic abilities in xenotransplantation model, in vitro colony- and spheroid-forming capabilities, expression of stemness-associated genes, and migratory capacity. Our findings not only address the value of a novel antigen, KIAA1114, as a potential diagnostic factor of human liver cancer, but also as an independent biomarker for identifying TIC populations that could be broadly applied to the heterogeneous HCC subtypes.X1110Nsciescopu